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DESCRIPTION
Cytotam 20 mg is a group of cancer control regimens known as antitumor, and especially for the type of antitumor known as antiestrogens. This is required in combination with other medicines to treat early breast cancer.
Cytotam 20 mg is a prescription drug that is provided only under the guidance of an oncologist.
INDICATIONS
Cytotam 20 mg is indicated for the treatment of early breast cancer in women who have been treated with surgery, radiation and chemotherapy.
Cytotam at a dose of 20 mg is indicated to reduce the risk of developing a more serious type of breast cancer in women who have had breast cancer that does not extend beyond the milk duct.

MECHANISM OF ACTION
Tamoxifen fights certain types of breast cancer, known as hormone-sensitive or estrogen receptor-positive breast cancer, by stopping the action of the hormone estrogen in the body. This inhibits the development of breast cancer cell types that need estrogen for growth and survival. It is also necessary for the treatment of breast cancer, which is launched or spread to other parts of the body.
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High plasma concentration is 40 mg / ml, and Tmax – 5 hours after dosing.
Cytotam 20 mg is metabolized in the liver
The elimination pathway is about 30%, and 65% is excreted from the body.
Half-life is 5 to 7 days.
Dosage management
- Usual Adult Dose for:
- Breast cancer: from 20 to 40 mg for 5 years, administered orally daily; doses> 20 mg obtained by dividing the dose (morning and evening) of DCIS followed by surgery and breast irradiation
- 20 mg 5 years orally daily
- Reduce the effect of breast cancer in women at increased risk of developing breast cancer
- 20 mg 5 years orally daily
- Used in Adult Dose for Adjuvant Breast Cancer
- 20 mg orally or 10 mg twice daily orally
- Duration: 5 years

Children’s dose for:
McCoon-Albright Syndrome (girls from 2 to 10 years old) – 20 mg once daily by oral route; Duration up to 12 months. Early puberty (girls from 2 to 10 years) – 20 mg once daily by oral route; Duration up to 12 months.
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Overdose:
No acute overdose in humans has been reported in animals. If you take a high dose, this leads to respiratory difficulties and convulsions, as well as to an unstable gait of a person, acute neurotoxicity, manifested by tremor, hyperreflexia and dizziness. There is no specific treatment for overdose. Therefore, provide symptomatic supportive measures for patients.

SIDE EFFECTS
- Common side effect:
- high tumor pain
- redness of the tumor
- hot flashes
- Dizziness
- thinning hair
- Weight loss
- Stomach ache
- Lost sexual abilities.
Some side effects can be serious, as it should, immediately tell your doctor:
- decreased appetite
- Vision problems
- Fever
- Bubbles
- Thirst
- muscle weakness
- restlessness
- an abscess on the eyes, face, lips, tongue, throat, ankles or legs

DRUG INTERACTION
When the simultaneous use of Cytotam 20 mg with a combination of anticoagulants such as coumarin will lead to an increase in anticoagulant effects may occur.
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Bromocriptine continues treatment with 20 mg of cytotam, will increase serum cytotam of 20 mg and N-dimethyl tamoxifen.
CONTRAINDICATIONS
Cytotam 20 mg is contraindicated in patients with known hypersensitivity to the drug or its components.
Cytotam 20 mg is contraindicated in women who need to continue treatment with anticoagulants such as coumarin.
Cytotam 20 mg is also contraindicated in women with a history of deep vein thrombosis or pulmonary embolism.
PREGNANCY AND LACTATION
Category D: Cytotam 20 mg when administered to pregnant women will harm the fetus. Women are advised to stop taking the drug for 2 months and not become pregnant while taking 20 mg of cytotam. And if sexually active, then non-hormonal contraceptives should be used.